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A combination of systemic nanoparticles for caveolae-mediated gene delivery to the brain
This study shows that systemic mannitol induces caveolae in the brain endothelium. Mannitol-modified nanoparticles exploit this to cross the BBB, enhancing gene delivery.
2026-05-20
Combined Denoising and Resolution Enhancement Algorithms for Intravital Two-Photon Imaging
The study compared several image processing techniques, finding that the enhanced Super-Resolution Radial Fluctuations (eSRRF) combined with a trained denoising model significantly improved spatial resolution and mitochondrial structure visualization compared to other algorithms. Algorithms Evaluated: The study tested Gaussian and median filtering against a trained denoising model, followed by resolution enhancement using either eSRRF or […]
2026-05-14
High-Throughput UVA-Based Thermal Shift Assays for Hydrophobic Proteins Using the qTOWER iris
This note demonstrates a UVA-based Thermal Shift Assay on the qTOWER iris, enabling sensitive detection of protein stability and expanding qPCR use to protein analysis.
2026-04-23
Microscopy-guided subcellular proteomic discovery by high-speed ultra-content photo-biotinylation
Syncell developed a method combining microscopy, photo-biotinylation, and mass spectrometry, enabling high-resolution mapping of proteins in subcellular regions, accelerating discoveries in spatial proteomics research.
2026-03-23
NEW: TIDeX – Total Ionizing Dose Instrument
The all-in-one X-ray platform designed to streamline Total Ionizing Dose (TID) effect testing with accuracy, control, and repeatability
2026-03-12
Non-invasive real-time pulsed Doppler assessment of blood flow in mouse ophthalmic artery
Imaging was performed under isoflurane anesthesia using the SkyScan 1276 instrument with an X-ray source voltage and current of 70 kV and 200 μA and a 1 mm Aluminum filter. A total of 1200 projection images were acquired at resolution of 13μm.
2026-02-06
Efficient DNA purification from cells: Automated workflows with sbeadex Lightning and CyBio FeliX
This application note presents a rapid, automated DNA purification workflow using the CyBio FeliX system with sbeadex Lightning technology, enabling high-quality results in just minutes while reducing hands-on time and increasing throughput.
2026-05-06
PHF19 drives the formation of PRC2 clusters to enhance motility in TNBC cells
Polycomb repressive complex 2 (PRC2) is a key regulator of transcriptional repression and chromatin organization, essential in development and disease. While its enzymatic activity is well characterized, the factors governing PRC2 subnuclear organization, particularly in cancer cells, are largely unknown. Here, the researchers integrate in situ subcellular proteomics, high-resolution imaging, and functional genomics to investigate […]
2026-04-14
Harnessing the Nanoflow cytometer Exoplorer to characterize surface proteins of Exosomes
miR-185-5p Derived From hUC-MSC Exosomes via Suspension Culture Under Hypoxic Conditions Promotes Scarless Wound Healing in Mice by Precisely Regulating Collagen I/III Regeneration
2026-03-19
Harnessing the WOLF Cell Sorter for Cutting‑Edge Senescence Research
Senescent Endothelial Cells in Cerebral Microcirculation Are Key Drivers of Age-Related Blood–Brain Barrier Disruption, Microvascular Rarefaction, and Neurovascular Coupling Impairment in Mice
2026-02-18
Metabolomic fingerprints of PAH exposure – identifying toxicological biomarkers in dynamic culture
This study not only highlights the use of spheroids for mechanistic toxicological studies but also provides a framework for identifying potential metabolic biomarkers of PAH exposure. Use of ClinoStar for hepatic HepG2 spheroids made the difference !
2026-02-05
Cutaneous T cell lymphoma atlas reveals malignant TH2 cells supported by a B cell-rich tumor microen
The study provides a high-resolution atlas of cutaneous T cell lymphoma, identifying that malignant cells resemble TH2 cells. It highlights how a B cell-rich microenvironment supports tumor growth, offering new targets for therapy.
2026-05-04
Comprehensive analysis of B cell repopulation in ocrelizumab-treated patients with MS
Using the Curiox Pluto platform to automate immune profiling, ocrelizumab’s effects in MS reveal repopulation of transitional naïve B cells at 6 months and linked shifts in T/myeloid markers and plasma proteins.
2026-04-07
Accelerating Antibody Discovery with the WOLF G2 Cell Sorter
Site-directed antibodies targeting driver mutations of the KRAS protein
2026-03-16
Use of Vizgen’s MERSCOPE Platform to Uncover New Insights about Aging
Microglia activation orchestrates CXCL10-mediated CD8+ T cell recruitment to promote aging-related white matter degeneration - peer-reviewed paper outlines aging-related changes in white matter by single-cell and spatial transcriptomics
2026-02-11
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Technologies