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A combination of systemic nanoparticles for caveolae-mediated gene delivery to the brain
This study shows that systemic mannitol induces caveolae in the brain endothelium. Mannitol-modified nanoparticles exploit this to cross the BBB, enhancing gene delivery.
2026-05-20
Quantitative Resolution Enhancement in In Vivo Two-Photon Intravital Imaging
Unlock high-resolution intravital imaging with advanced two-photon microscopy and computational enhancement. Visualize dynamic cellular processes in vivo with clarity, precision, and real-time insight.
2026-05-18
Bruker MRI CryoCoils provide tremendous benefits compared to standard room-temperature RF-coils
Bruker's MRI CryoProbe with MRI cryocooler increases sensitivity of in-vivo probes by factors of 2.5 to 5.3 compared to standard room temperature RF-coils
2026-02-10
CXCL12+ fibroblastic reticular cells in lymph nodes facilitate immune tolerance
The popliteal LNs were exposed surgically and confocal intravital imaging was performed (IVM-CMS3). Twenty-five Z-stack images were obtained with a 3 μm axial interval. Time-lapse images were obtained at a 1-minute time interval for 20 minutes.
2026-01-26
Reanalyze your in-vivo optical images with Aura Software
Aura is a free license software application produced by Spectral Instruments Imaging, a Bruker Company.
2025-10-23
Optimizing Substrate Dosing for ReliableBioluminescence Imaging (BLI)
Bioluminescence imaging relies on precise D-luciferin administration, as dosing variability impacts signal intensity and data consistency. Standardizing substrate delivery is essential for reproducible and high-quality in vivo imaging results.
2025-09-18
Combined Denoising and Resolution Enhancement Algorithms for Intravital Two-Photon Imaging
The study compared several image processing techniques, finding that the enhanced Super-Resolution Radial Fluctuations (eSRRF) combined with a trained denoising model significantly improved spatial resolution and mitochondrial structure visualization compared to other algorithms. Algorithms Evaluated: The study tested Gaussian and median filtering against a trained denoising model, followed by resolution enhancement using either eSRRF or […]
2026-05-14
Non-invasive real-time pulsed Doppler assessment of blood flow in mouse ophthalmic artery
Imaging was performed under isoflurane anesthesia using the SkyScan 1276 instrument with an X-ray source voltage and current of 70 kV and 200 μA and a 1 mm Aluminum filter. A total of 1200 projection images were acquired at resolution of 13μm.
2026-02-06
Can you solve mouse CT imaging with 50um spatial resolution ?
MOLECUBES, a Bruker Company offers small footprint microCT for mice and rats, which meets most of your needs for in-vivo analysis and doesn't sacrifice the budget.
2025-10-22
Subcutaneous delivery of MSC induces immunoregulatory effects in the lymph node
Mice were imaged under anaesthesia (2.5% isoflurane in oxygen), daily until the bioluminescence signal disappeared. Imaging was performed in an Ami-HTX Small Animal Imager and analysed with Aura Imaging Software, from Spectral Instruments Imaging.
2025-09-12
New product launch: InAlyzer2, Medikors
Next generation DXA Precision Analysis Technology
2026-05-11
Dynamis DNP – Enhancing MRI experiments with unprecedented sensitivity gains
For preclinical MRI, dissolution DNP unlocks real-time metabolic imaging with hyperpolarized tracers, offering new insights into disease progression and therapeutic response.
2026-02-03
Development of new albumin‑binding radiotracers for PET imaging of CSF
In this study by Peltoniemi et al., PET/CT imaging using the X-CUBE (CT) and ß-CUBE (PET) was used to non-invasively visualize cerebrospinal fluid (CSF) flow and glymphatic system dynamics in rats.
2025-11-28
Elevating Intravital Imaging with AI: Introducing the AI-Image Denoiser
AI-Image Denoiser, our best-in-class, AI-powered image enhancement software designed specifically for high-speed intravital microscopy.
2025-10-21
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