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Optimizing Substrate Dosing for ReliableBioluminescence Imaging (BLI)
Bioluminescence imaging relies on precise D-luciferin administration, as dosing variability impacts signal intensity and data consistency. Standardizing substrate delivery is essential for reproducible and high-quality in vivo imaging results.
2025-09-18
Subcutaneous delivery of MSC induces immunoregulatory effects in the lymph node
Mice were imaged under anaesthesia (2.5% isoflurane in oxygen), daily until the bioluminescence signal disappeared. Imaging was performed in an Ami-HTX Small Animal Imager and analysed with Aura Imaging Software, from Spectral Instruments Imaging.
2025-09-12
Incorporation of SARS-CoV-2 spike NTD to RBD protein vaccine improves immunity against viral variant
By fusing the spike protein's terminal domain (NTD) with its receptor-binding domain (RBD), researchers have engineered a protein vaccine that significantly amplifies both T-cell responses and antibody breadth.
2025-06-25
Spatial Proteomics: Charting the Protein Landscape in Tissues
Spatial proteomics uncovers the spatial distribution of proteins within tissues, enabling detailed analysis of cellular functions, disease progression, and intercellular interactions beyond the limits of traditional bulk proteomic approaches.
2025-06-06
Curious how PET imaging and reporter gene tracking are transforming CAR-T cell therapy in oncology?
Recorded webinar is recommended if you are working or you are interested by translational studies in oncology, immune therapy, and biomedical imaging.
2025-06-02
Advanced spatial biology sheds new light on therapeutic research
See how high-resolution multiplex immunofluorescence imaging can elucidate the important role the immune system plays in health, disease, and drug development.
2025-04-22
Monitoring mRNA vaccine antigen expression in vivo using PET/CT
The aim of this study was to evaluate the ability of PET/CT imaging to track mRNA vaccine antigen expression in mammalian systems. The researchers used eDHFR as a PET reporter gene, fused to the SARS-CoV-2 spike protein.
2025-09-08
Growing Mature Biofilms for Antimicrobial Screening, Host-pathogen Interactions, and Adhesion
We present the BioFlux shear flow system, a microfluidic flow cell array that enables the growth of biofilms in precisely controlled conditions, including shear stress, temperature, and environmental gas.
2025-06-18
Integrated Biomarker Discovery and T Cell Analysis using the IsoSpark and Beacon Platforms
Bruker’s proteomic barcode and optofluidic technologies synergize to provide researchers with comprehensive understanding of T cell biology.
2025-06-05
Cytek Biosciences introduces the affordable, user-friendly Cytek Muse Micro System
The Muse Micro cell analyzer is an affordable option that simplifies flow cytometry while enhancing ease-of-use, precision and versatility.
2025-05-13
An immunophenotype-coupled transcriptomic atlas of human hematopoietic progenitors
Analysis of the human hematopoietic progenitor compartment is being transformed by single-cell multimodal approaches.
2025-04-15
Generating High-Quality cDNA Libraries for Efficient Sequencing of T-cell Receptor mRNA
Single-cell omics provide undiluted information about individual cells, such as transcription levels and sequences of highly variable proteins.Miniaturizing the assay helps scale down analysis to the single-cell level without sacrificing data quality
2025-07-02
IsoSpark in HIV research: quantitation of proteins in the culture supernatants.
Exciting example of use 22-plex antibody with the IsoPlexis Human Adaptive Immune Panel (Bruker Cellular Analysis) in HIV research.
2025-06-12
Control of behavioral uncertainty by divergent frontal circuits
Preprint on bioRxiv shows that plasma p-tau181, NfL, and GFAP effectively differentiate Alzheimer’s from FTD and DLB, while Aβ₁₋₄₂/₁₋₄₀ adds little diagnostic value.
2025-06-04
Optimized rare cell isolation for mouse and human samples
This application note introduces the new in situ rinse program. This workflow delivers the same high purity of rare cells as the traditional “serial program” and additionally significantly enhances throughput.
2025-04-29
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Technologies