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High-Throughput UVA-Based Thermal Shift Assays for Hydrophobic Proteins Using the qTOWER iris
This note demonstrates a UVA-based Thermal Shift Assay on the qTOWER iris, enabling sensitive detection of protein stability and expanding qPCR use to protein analysis.
2026-04-23
PHF19 drives the formation of PRC2 clusters to enhance motility in TNBC cells
Polycomb repressive complex 2 (PRC2) is a key regulator of transcriptional repression and chromatin organization, essential in development and disease. While its enzymatic activity is well characterized, the factors governing PRC2 subnuclear organization, particularly in cancer cells, are largely unknown. Here, the researchers integrate in situ subcellular proteomics, high-resolution imaging, and functional genomics to investigate […]
2026-04-14
Combining GrowDex and spheroONE for automated and highly reproducible 3D cell culture workflows
This application note demonstrates the compatibility of spheroONE and GrowDex to automate 3D cell culture workflows. spheroONE is a nanoliter dispenser enabling sorting and isolation of spheroids and organoids.
2026-02-25
The Path to Clinical Relevance: Moving from Spatial Transcriptomics to Protein Profiling
Spatial biology is a rapidly evolving discipline that advances human health by leveraging imaging technologies. It encompasses research activities ranging from whole-transcriptome profiling to clinically impactful single-protein biomarker tests.
2025-12-02
Image-activated cell sorting
The NanoCellect VERLO Image-Guided Cell Sorter is mentioned in the attached Nature Reviews Bioengineering paper (Ding et al., 2025) reviewing commercially available Image-Activated Cell Sorting systems.
2025-09-16
Control of behavioral uncertainty by divergent frontal circuits
Preprint on bioRxiv shows that plasma p-tau181, NfL, and GFAP effectively differentiate Alzheimer’s from FTD and DLB, while Aβ₁₋₄₂/₁₋₄₀ adds little diagnostic value.
2025-06-04
Standardized Thawing and Sample Preparation of ARCTis Cryopreserved Human Tumor Cells
The standardized and automatic handling of cryopreserved biological samples plays an increasingly important role in today’s in vitro testing. This is due to the trend to develop more complex disease models to increase the data quality of studies.
2026-03-30
Integrative multi-omics reveals a regulatory and exhausted T-cell landscape in CLL
T-cell exhaustion contributes to immunotherapy failure in chronic lymphocytic leukemia (CLL). T cells from CLL patients' blood, bone marrow, and lymph nodes were analyzed using single-cell RNA sequencing, mass cytometry, and tissue imaging.
2026-02-12
Genotype-Specific Macrophage Programs in the NSCLC Microenvironment
Understanding cell-cell interactions within the tumor-immune microenvironment is crucial for advancing cancer therapies. Macrophages show highly variable roles in tumor progression and response, yet the drivers of this complexity remain unclear.
2025-11-26
Applications: Phase Contrast and Fluorescence Microscopy
Phase contrast and fluorescence microscopy reveals structural and molecular details in cells. Lumascope microscopes are ideally suited for research that requires both, for example this cancer-related study.
2025-08-18
Optimized rare cell isolation for mouse and human samples
This application note introduces the new in situ rinse program. This workflow delivers the same high purity of rare cells as the traditional “serial program” and additionally significantly enhances throughput.
2025-04-29
Molecular and Spatial Drivers of Immunotherapy Response in Mucosal Melanoma
Findings suggest that distinct genomic features, tumor states, and microenvironments differentiate ICB response and progression in MM, highlighting key tumor-intrinsic and microenvironmental factors associated with prognosis.
2026-03-18
Use of Vizgen’s MERSCOPE Platform to Uncover New Insights about Aging
Microglia activation orchestrates CXCL10-mediated CD8+ T cell recruitment to promote aging-related white matter degeneration - peer-reviewed paper outlines aging-related changes in white matter by single-cell and spatial transcriptomics
2026-02-11
Gentle Cell Sorting Advancing ALS Research
Researchers using iPSC-derived neurons and glia for ALS models have found that WOLF’s gentle, low-pressure sorting preserves fragile cells’ viability and function—unlike traditional droplet sorters.
2025-10-15
Generating High-Quality cDNA Libraries for Efficient Sequencing of T-cell Receptor mRNA
Single-cell omics provide undiluted information about individual cells, such as transcription levels and sequences of highly variable proteins.Miniaturizing the assay helps scale down analysis to the single-cell level without sacrificing data quality
2025-07-02
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Technologies