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Age-associated B cells are heterogeneous and dynamic drivers of autoimmunity in mice.
Transfer and labeling studies demonstrated that ABCs are dynamic, rapidly turning over. scRNA-seq identified B cell clones present in multiple subsets, revealing that ABCs can be plasmablast precursors or undergo cycles of reactivation. Deletion of CD11c-expressing B cells revealed a direct role for ABC-like B cells in lupus pathogenesis.
Related technologies: Antibodies & ReagentsCell SortingSpectral flow cytometry
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