Pulsoid – IZON

High-resolution, nanoparticle measurement

The Pulsoid provides particle-by-particle insights, allowing you to explore distributions, heterogeneity, and subtle population differences that may otherwise go undetected. The precision and consistency of solid-state nanopores enable accurate measurement of small particles from 40nm to 140nm. Size accuracy is exceptionally high, demonstrated by 99.7% agreement with TEM for NIST-traceable polystyrene standards.

Single-particle analysis ensures the Pulsoid maintains accuracy even when analysing polydisperse samples. A solid-state silicon nanopore housed in an easy-to-clean fluid cell reduces handling, maintenance, and calibration between runs. The result is faster workflows and higher throughput. The Pulsoid measures concentration by directly counting individual particles, delivering a linear response across a wide concentration range.

This ensures measured changes reflect real differences in particle number, not artefacts, making the Pulsoid well suited to formulation work, process monitoring, and comparability studies.The Pulsoid measures particle size and zeta potential simultaneously on a particle-by-particle basis, revealing surface charge detail that ensemble techniques average away.
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Resolving charge distributions and subpopulations provides clearer insight into formulation behaviour, stability, and process-related changes, particularly for heterogeneous samples, for volumes of 70µL. At the heart of the Pulsoid is a precision-manufactured silicon nanopore chip. Its fixed pore geometry delivers consistent, repeatable single-particle measurements with the resolution required for high-quality nanoparticle analysis.
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As particles pass through the nanopore, brief changes in ionic current are measured. Signal magnitude correlates with particle size, event frequency reflects concentration, and event duration enables zeta potential measurement. The result is highly detailed, particle by particle characterisation. Testing Speed per Sample: 2 to 5 minutes². Size Accuracy: 100% ± 2%¹. Concentration Range: 1 x 10⁹ to 1 x 10¹² particles/mL.

More info at: Pulsoid – Advanced Nanoparticle Characterisation | Izon