Spectral Instruments Imaging manufactures instruments for preclinical optical (bioluminescent, fluorescent) and X-ray imaging.
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Development of Image-Based In Vitro/In Vivo Platform for Targeting CAFs
Explore cutting-edge methods to advance tumor microenvironment (TME) research, including:
- Innovative Co-culture Systems: Learn how fluorescent protein-labeled cell lines (e.g., iRFP720, pKatushka) are used to create in vitro co-culture systems that replicate TME’s extracellular and cellular elements.
- Translational Insights: Discover how in vitro experiments align with in vivo data, highlighting CAF-mediated tumor cell protection and the reshaping of cancer cell clusters to mimic human tumor tissue.
- Key Findings: Gain insights into immune cell cytotoxicity kinetics and tumor resistance trends observed consistently across in vitro and in vivo studies.
Related technologies: Fluorescence, luminescence, X-ray, radiographic imaging
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