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Optical Imaging with Cherenkov Luminescence Inform PET and SPECT Study Design
Optical imaging has become an essential component of preclinical imaging workflows, providing rapid, sensitive, and
cost-effective insights into biological processes prior to more resource-intensive nuclear imaging modalities such as
positron emission tomography (PET) and single-photon emission computed tomography (SPECT). Among optical
modalities, Cherenkov luminescence imaging (CLI) offers a unique and direct link to radionuclide imaging because the
emitted signal originates from the same radioactive decay processes used in PET and certain SPECT studies. This
intrinsic connection positions CLI as a powerful bridge technology for translational imaging workflows – particularly
when implemented on highly sensitive optical imaging platforms, such as the Spectral Lago X, Ami HTX, and Kino.
Related technologies: Fluorescence, luminescence, X-ray, radiographic imaging
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