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Molecular and Spatial Drivers of Immunotherapy Response in Mucosal Melanoma
Findings suggest that distinct genomic features, tumor states, and microenvironments differentiate ICB response and progression in MM, highlighting key tumor-intrinsic and microenvironmental factors associated with prognosis.
2026-03-18
Whole genome analysis and in vivo safety assessment of probiotic candidate Lactobacillus acidophilus
Probiotics, particularly strains of lactic acid bacteria (LAB), are recognized for their beneficial effects on gut health. Lactobacillus acidophilus L177, a promising probiotic strain isolated from canine feces, was evaluated for safety and probiotic.
2026-03-10
Integrative multi-omics reveals a regulatory and exhausted T-cell landscape in CLL
T-cell exhaustion contributes to immunotherapy failure in chronic lymphocytic leukemia (CLL). T cells from CLL patients' blood, bone marrow, and lymph nodes were analyzed using single-cell RNA sequencing, mass cytometry, and tissue imaging.
2026-02-12
RareCyte Spatial Biology – Immunofluorescence imaging workshop at Masaryk University, Brno
Join ACCELA and RareCyte for this special Spatial Biology - Immunofluorescence imaging workshop at Masaryk University, CAMPUS Bohunice, Meeting room in E24 (Biologypark), Studentská 812/6, Brno, Czech Republic. Monday, February 9, 2026, 9 AM.
2026-01-30
Genotype-Specific Macrophage Programs in the NSCLC Microenvironment
Understanding cell-cell interactions within the tumor-immune microenvironment is crucial for advancing cancer therapies. Macrophages show highly variable roles in tumor progression and response, yet the drivers of this complexity remain unclear.
2025-11-26
Preclinical Development for Therapy of Hard-to-Treat PD-L1-Positive Solid Tumors
They developed MDG1015 — CD8⁺ TCR-T cells armored with a PD1-41BB costimulatory switch protein (CSP) that converts PD-L1–mediated inhibition into activation. In vitro, they selectively kill PD-L1⁺ tumor cells while sparing non-target cells.
2025-11-17
Introducing IVM-FS: Real-Time Cellular Insightsinto Rats and Other Medium-Sized Animals
Rats are increasingly valued for intravital imaging due to their larger body size and organ systems, which enable more precise surgical preparation, stable window implantation, and repeated long-term imaging - advantages over mice.
2026-03-03
Metabolomic fingerprints of PAH exposure – identifying toxicological biomarkers in dynamic culture
This study not only highlights the use of spheroids for mechanistic toxicological studies but also provides a framework for identifying potential metabolic biomarkers of PAH exposure. Use of ClinoStar for hepatic HepG2 spheroids made the difference !
2026-02-05
Direct delivery of plasmin using clot-anchoring thrombin-responsive nanoparticles
The targeted fibrinolytic efficacy of the plasmin-loaded CTNPs was then evaluated under flow using the Bioflux microfluidic device.
2026-01-28
Perfusion: The Beating Heart of Single-Cell Biology and Cancer Immunotherapy
Single-cell biology has transformed our ability to uncover cellular diversity and dynamic behavior within complex tissues that are otherwise masked in population-level analyses.
2025-11-24
Introducing EOS6: High content – live cell analysis inside your incubator
Built to support multiple users and applications, the EOS6 can run up to six microplates in parallel, flask, dishes, slides… Users can schedule experiments at different image acquisition frequencies and magnifications in parallel.
2025-10-24
Comparing Microscoop with Proximity Labeling Techniques APEX2 and BioID
Discover how Microscoop, APEX2, and BioID offer unique advantages for mapping protein-protein interactions—whether in fixed tissue or live cells. Learn which method fits your proteomics research best!
2026-02-23
Low-Cost Small Molecules to Replace bFGF
Low-Cost Small Molecules to Replace bFGF, Enabling Stable and Scalable Cell Growth Benefitting R&D and Industrial Application
2026-02-04
Functional, Fast, and Unbiased TCR Discovery with Bruker’s Optofluidic Platform
Identifying antigen specific T-cell receptors (TCRs) is critical for advancing TCR-T therapies, vaccines, and infectious disease research. Yet, traditional peptide-MHC tetramer/dextramer sorting only tells part of the story.
2026-01-23
Advances in Biofilm Research: How the Experts are Overcoming Obstacles
There are plenty of areas of interest when working with biofilms. In this article we focus on two major ones: biofilm drug resistance and antibiofilm drug development and the approach one can take in research.
2025-11-19
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